Stem Cells Take Aim
Programming cells to home to specific tissues may enable more effective cell-based therapies
Stem cell therapies hold enormous potential to address some of the most tragic illnesses, diseases, and tissue defects world-wide. However, the inability to target cells to tissues of interest poses a significant barrier to effective cell therapy. To address this hurdle, researchers at Brigham and Women’s Hospital (BWH) have developed a platform approach to chemically incorporate homing receptors onto the surface of cells. This simple approach has the potential to improve the efficacy of many types of cell therapies by increasing the concentrations of cells at target locations in the body.
These findings are published online in the journal Blood on October 27, 2011.
Image courtesy of Brigham and Women's Hospital
For this new platform, researchers engineered the surface of cells to include receptors that act as a homing device. “The central hypothesis of our work is that the ability of cells to home to specific tissues can be enhanced, without otherwise altering cell function,” said Jeffrey M. Karp, HMS assistant professor of medicine and co-director of the Regenerative Therapeutics Center at BWH and “By knowing the ‘zip code’ of the blood vessels in specific tissues, we can program the ‘address’ onto the surface of the cells to potentially target them with high efficiencies.”
While conventional cell therapies that include local administration of cells can be useful, they are typically more invasive with limited potential for multiple doses. “You can imagine, that when the targeted tissue is cardiac muscle, for example to treat heart attacks or heart failure, injecting the cells directly into the heart can be an invasive procedure and typically this approach can only be performed once,” said Dr. Karp, also a principal faculty member of the Harvard Stem Cell Institute and affiliate faculty at Harvard-MIT Division of Health Sciences and Technology.
Adapted from a Brigham and Women’s Hospital news release. For the complete story, please visit the BW newsroom
Brigham and Women’s Hospital is a teaching affiliate of Harvard Medical School
Stem cells and recovery:-
Injection of stem cells will yield to a very slow recovery process. This is because there is not enough (stem) cells to continue the treatement.
It is better off to turn (all) cells in the body to stem level.
These cells have a short DNA string. Mostly an end of codon and a start codon. This is like: start_codon – string, and end_codon. THEN, the phoshorous plus the oxygen binds together to work as stem.
The way to turn a few fat (and/or other casual cells) to stem will be by cutting the long cell DNA to a minimum. Cyanide consumes all oxygen found. Once injected (with Insulin) to blood, with the help of insulin (to turn the fat to glucose, which has oxygen); once in the casual cells, the cyanide will “eat-up” the DNA by consuming its oxygen. FORMING STEM.
Recap:
Inject a liguid containing centrifuged Cyanide + Insulin.
God Speed.
Dr. A
Like the AIDS cure, mentioned on other page, the “homing” targets cells with different resistance. This is as simple as Hydrogen Peroxide. It will brush to blocked cells pour.
How does this relate to blood conventions?
The only problem with hemoglobin is that it is not really a cell. So the H2O2 will filter the blood. This is like a ‘traffic poll’.
Other chemicals can be used to concentrate the blood to a specific local location. Such as injection of good or bad cholesterol. Normally, in theory, shows that cholesterol barricates the bad cancerous cells to one location. SO, heavy water and cholesterol, which is blood + lipid-fat). targets the cancer zone.
Thank you and god bless.
Dr. A
Adult fat contains stem cells. Can they be injected into lumbar disks? Who is doing this process and what are the stats regarding full recovery? I do not want to have the surgery associated with this degenerative disease. (Breaking bones and inserting pieces of metal, therefore restricting movement.)
Carol
las cel madre podrian curarme un cuadro de enfisema moderado?.Si es asi me ofresco como voluntario para experimentarlo.espero respuesta.gracias
I have hereditary cerebellar degeneration. Is there any research being done in this area with stem cells? if not here in US, then maybe you know of something internationally. I would be so grateful if you could let me know. Thank you.
My son, Mike Kauffer, has a spinal cord injury and as a result is paralyzed from his chest down. His spinal cord was not severed but twisted.
I would like very much to investigate stem cells implants for his rehabilitation. I would be happy to bring him to you for a check up.
Any information regarding this proceedure would be appreicated.
Thank you,
Sandra Kauffer
Blood forming stem cell,,,for leukemia.
Your great research make this cell ,discovery components of this cell,,,Development of medicines,,,
For Leukeima,,,,
Thank you,,,Dr.Karp